Biohacking Knowledge Base — Research & Field Notes

Diabetics on metformin live longer than non-diabetics not on it. This observation launched the first FDA-sanctioned longevity trial. Here's what TAME actually found — including the exercise interference problem that changed how biohackers use it.

Semax and Selank are approved pharmaceuticals in Russia — not research chemicals but actual prescription drugs with clinical evidence. They have distinct mechanisms and distinct applications. Here's how they differ and how to use them.

Methylene blue has a hormetic dose-response that most people get completely wrong. The same mechanism that makes it an antioxidant at low dose makes it pro-oxidant at high dose. Less is more — and this is pharmacology, not a cliché.

Most men walking around with suboptimal testosterone have normal total testosterone. Their doctor says everything is fine. They feel terrible anyway. The problem is what's not being measured.

Most peptide failures have nothing to do with the peptide. They happen in a refrigerator, a reconstitution syringe, or a storage cabinet. The compound is destroyed before it's ever used.

A 16-hour intermittent fast and a 72-hour extended fast are different interventions at the cellular level. Here's the complete physiological cascade — hour by hour — and what each phase actually does.

BPC-157 and TB-500 have complementary mechanisms that produce additive repair signaling. BPC-157 drives local angiogenesis. TB-500 mobilizes stem cells systemically. Together they cover what neither does alone.

There is a single variable that determines whether sleep peptides produce their documented effects or do nothing at all. This is the variable almost no one mentions — and it explains most of the discrepancy in results.

Before GnRH. Before LH. Before testosterone. There is Kisspeptin — the neuropeptide that initiates the entire HPT cascade. Working with this signal is a fundamentally different approach to testosterone optimization.

Cerebrolysin is the only neuropeptide preparation with clinical evidence of neurotrophic activity comparable to endogenous NGF. Here's what the clinical data shows and what biohackers should realistically expect.

In the STEP trials, 40% of weight lost on Semaglutide was lean mass. That's not acceptable. Here's the week-by-week titration schedule and the non-negotiable support stack that prevents it.

The honest answer depends on what type of tissue you're dealing with and how long it's been there. A field report from someone who reversed approximately 80% of AAS-induced gynecomastia of 10+ years without surgery.

Two enzymes derived from fermented foods have accumulated enough clinical evidence to warrant serious attention from anyone interested in cardiovascular longevity. Here's what the data actually shows — not the marketing version.